➽Ni Mediated Process Optimization (NiNPO)
Catalysis in Flow: Nickel-Catalyzed Synthesis of Primary Amines from Alcohols and NH3
†Department of Chemical Engineering and ‡Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ , U.K.
ACS Sustainable Chem. Eng., 2018, 6 (4), pp 5479–5484
DOI: 10.1021/acssuschemeng.8b00338
Publication Date (Web): March 5, 2018
Copyright © 2018 American Chemical Society
*(K.H.) E-mail: k.hellgardt@imperial.ac.uk., *(K.K.H.) E-mail: mimi.hii@imperial.ac.uk.
Synopsis
A high pressure continuous flow system has been designed to facilitate Ni-catalyzed monoalkylation of ammonia by alcohols with high selectivities.
Abstract
A highly selective synthesis of primary amines from alcohols and NH3 was achieved on using a commercially available Ni catalyst, without adding H2. Using a continuous flow reaction platform, the amination of aliphatic alcohols can be achieved in good yields and selectivities, as the accumulation of water byproduct can be removed. Competitive formation of the nitrile side-product was suppressed when the catalyst was prereduced. Modes of catalyst deactivation were also briefly examined.
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acssuschemeng.8b00338.
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