Cobalt-Catalyzed Carbonylation of C(sp2)–H Bonds with Azodicarboxylate as the Carbonyl Source
† CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China
‡ University of Chinese Academy of Sciences, Beijing 100049, China
§ ShanghaiTech University, Shanghai 20120, China
Org. Lett., 2016, 18 (22), pp 5960–5963
DOI: 10.1021/acs.orglett.6b03111
Publication Date (Web): November 8, 2016
Copyright © 2016 American Chemical Society
*E-mail: aozhang@simm.ac.cn.
Abstract
A novel and efficient approach for the C(sp2)–H bond carbonylation of benzamides has been developed using stable and inexpensive Co(OAc)2·4H2O as the catalyst and the commercially available and easily handling azodicarboxylates as the nontoxic carbonyl source.
A broad range of substrates bearing diverse functional groups were tolerated.
This is the first example where cobalt-catalyzed C(sp2)–H bond carbonylation occurs with azodicarboxylate as the carbonyl source.
Supporting Information
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.orglett.6b03111.
- Experimental procedures, spectral and analytical data, copies of 1H and 13C NMR spectra for new compounds (PDF)
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