3-Nitropropionic Acid (3-NPA), a Potent Antimycobacterial Agent from Endophytic Fungi: Is 3-NPA in Some Plants Produced by Endophytes?
Program of Biotechnology and Department of Chemistry, Faculty of Science, Chulalongkorn University, Thailand, Department of Microbiology, Faculty of Science, Mahidol University, Thailand, Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand, Center for Biotechnology, Institute of Science and Technology for Research and Development, Mahidol University, Thailand, and National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, 113 Paholyothin Road, Klong 1, Klong Luang, Pathumthani, 12120, Thailand
J. Nat. Prod., 2005, 68 (7), pp 1103–1105
DOI: 10.1021/np050036a
Publication Date (Web): June 22, 2005
Copyright © 2005 American Chemical Society and American Society of Pharmacognosy
Abstract
3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 μM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).
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