A Concise and Convergent Synthesis of PA-824
Department of Chemistry, Frick Chemical Laboratory, Princeton University, Princeton, New Jersey 08544, United States
J. Org. Chem., 2010, 75 (21), pp 7479–7482
DOI: 10.1021/jo1015807
Publication Date (Web): October 7, 2010
Copyright © 2010 American Chemical Society
Abstract
An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.
Supporting Information
1H NMR and 13C NMR spectra of 1 and 9−14 and chiral SFC data for 10 and 1. This material is available free of charge via the Internet at http://pubs.acs.org.
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