Generating Better Medicines for Cancer
‡ Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States
§Eshelman School of Pharmacy, 
Lineberger Comprehensive Cancer Center, 
Department of Chemistry, #Department of Pharmacology, 
̂Department of Biomedical Engineering, □Carolina Center of Cancer Nanotechnology Excellence, 
Institute for Advanced Materials, and ●Institute for Nanomedicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States
Lineberger Comprehensive Cancer Center, Department of Chemistry, #Department of Pharmacology, ̂Department of Biomedical Engineering, □Carolina Center of Cancer Nanotechnology Excellence, Institute for Advanced Materials, and ●Institute for Nanomedicine, University of North Carolina, Chapel Hill, North Carolina 27599, United States
■ Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States
▲ Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States
ACS Macro Lett., 2013, 2 (5), pp 393–397
DOI: 10.1021/mz400116a
Publication Date (Web): April 24, 2013
Copyright © 2013 American Chemical Society
*E-mail: desimone@unc.edu.
Abstract
The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT (Particle Replication In Nonwetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physicochemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability, and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.
Citing Articles
Citation data is made available by participants in CrossRef's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.
This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Magnetic Norbornene Polymer as Multiresponsive Nanocarrier for Site Specific Cancer Therapy
Vijayakameswara Rao N, Mutyala Naidu Ganivada, Santu Sarkar, Himadri Dinda,Koushik Chatterjee, Tanmoy Dalui, Jayasri Das Sarma, and Raja ShunmugamBioconjugate Chemistry2014 25 (2), 276-285
Getting Better Medicines with Small Heterocycles 2014;
返信削除