2018年6月25日月曜日

ぜんだま水素研究会(1)

私の FBOOKにも書いておいた!!

 

備忘録 0625/18 です。

 

ご参考 までに!!!

 

 

★ ラジカル水素・カウント式 創薬考(3)

ある種の 医薬品のなかには

丁度良い 水素ラジカルの供受

を行う= カプトデイテイブ水素

化合物が あるのでその数と薬効の

幅広さ (=プレイオトロピック効果)

について 自由に考察 する考え方で

古い医薬品分子を ふるいにかけ

解析して行く!!

創薬=リノベーション 即ち簡便な

ワンストップ!創薬!!の途を拓く!!

すなわち!!

拓く事は 比較することである!!

2018年6月20日水曜日

Curcuminoids Antioxidative Signal Modulation Pathway 2018


Article



Curcuminoids Modulate the PKCδ/NADPH Oxidase/Reactive Oxygen Species Signaling Pathway and Suppress Matrix Invasion during Monocyte–Macrophage Differentiation

Department of Molecular Biology and Human Genetics and Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan
§ Center of Medical Genetics, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, United States
J. Agric. Food Chem., 2015, 63 (40), pp 8838–8848
DOI: 10.1021/acs.jafc.5b04083
Publication Date (Web): September 28, 2015
Copyright © 2015 American Chemical Society
*Tel: +886-3-856-5301, ext 2683. Fax: +886-3-856-1422. E-mail: imyenjh@mail.tcu.edu.tw.

Abstract


Abstract Image
 
 
 
Monocyte recruitment and invasion play critical roles in the initiation and progression of atherosclerosis. The reduction in monocyte adhesion and infiltration is thought to exert antiatherosclerotic effects. Curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the major active components of curcuminoids and exhibit several biological activities, including anti-inflammatory, anticarcinogenic, and hypocholesterolemic activities. The aim of this study was to investigate the antiatherogenic effects and mechanisms of curcuminoids during monocyte to macrophage differentiation. The results showed that curcumin, DMC, and BDMC (20 μM) suppressed matrix invasion from 100.0 ± 5.0% to 24.8 ± 1.4%, 26.6 ± 2.9%, and 33.7 ± 1.7%, respectively, during PMA-induced THP-1 differentiation. We found that curcuminoids significantly reduced PMA-induced CD11b and MMP-9 expression by THP-1 cells. Production of reactive oxygen species (ROS) induced by PMA (126.7 ± 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 ± 7.8%, 87.8 ± 8.2%, and 89.8 ± 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression. We demonstrated that curcuminoids inhibited NADPH oxidase through the down-regulation of NOX2 expression and the reduction of p47phox membrane translocation. Moreover, we found involvement of PKCδ in the PMA-induced NOX2, CD11b, and MMP-9 mRNA expression. Curcumin, DMC, and BDMC decreased the active form of PKCδ protein stimulated by PMA in THP-1 cells. Overall, our results reveal that curcuminoids suppress matrix invasion through the inhibition of the PKCδ/NADPH oxidase/ROS signaling pathway during monocyte–macrophage differentiation.
The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.5b04083.
  • Primers used in RT-Q-PCR (Table S1) (PDF)

Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.
Facebook WeChat Email Addthis
Explore by:

Metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on
the Altmetric Attention Score and how the score is calculated.

Article Views: 557 Times
Received 19 August 2015
Date accepted 24 September 2015
Published online 28 September 2015
Published in print 14 October 2015
+
Altmetric Logo Icon More Article Metrics
Chemical & Engineering News: Latest News
ACS Axial: Your Bond With Chemistry Research

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

Hydrogen Aromatic Collision Pathway 2018


Article




Ionization and Single and Double Electron Capture in Proton–Ar Collisions

 

 

Laboratorio Asociado al CIEMAT de Física Atómica y Molecular en Plasmas de Fusión, Departamento de Química, módulo 13, Universidad Autónoma de Madrid, 28049 Madrid, Spain
J. Phys. Chem. A, 2018, 122 (9), pp 2523–2534
DOI: 10.1021/acs.jpca.7b11769
Publication Date (Web): February 9, 2018
Copyright © 2018 American Chemical Society
*L. Méndez. E-mail: l.mendez@uam.es.

 Note

This paper was published ASAP on February 22, 2018, with no labels for equations 45 to 49. The corrected version was published on February 23, 2018.

 Special Issue

Published as part of The Journal of Physical Chemistry virtual special issue “Manuel Yáñez and Otilia Mó Festschrift”.
 
 

Abstract

Abstract Image
 

 

 

Total cross sections for formation of H and H–, and electron production, in H+ + Ar collisions have been calculated at energies between 100 eV and 200 keV by employing two methods: for E < 10 keV, a semiclassical treatment with an expansion in a basis of electronic wave functions of the ArH+ quasimolecule and, for E > 10 keV, the switching-classical-trajectory-Monte Carlo method (s-CTMC). The semiclassical calculation involves transitions to molecular autoionizing states, calculated by applying a block-diagonalization technique. The s-CTMC method is adept to treat two-electron processes and yields total cross sections for H– formation in reasonably good agreement with the experimental data.

 
 
Cross sections for electron- and H-production processes, which are dominated by one-electron transitions, are in good agreement with the experimental data.

  • Positron Scattering from Methyl Halides
    The Journal of Physical Chemistry A
    , , , and
    Abstract: The well-known spherical complex optical potential (SCOP) and complex scattering potential-ionization contribution (CSP-ic) methods with appropriate modifications are applied to the CH3X (X = F, Cl, Br, and I) molecules to compute positron scattering ...
  • Hydrophobic Collapse in N-Methylacetamide–Water Mixtures
    The Journal of Physical Chemistry A
    , , , , , , and
    Abstract: Aqueous N-methylacetamide solutions were investigated by polarization-resolved pump–probe and 2D infrared spectroscopy (2D IR), using the amide I mode as a reporter. The 2D IR results are compared with molecular dynamics simulations and spectral ...
Explore by:


Metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Article Views: 145 Times
Received 29 November 2017
Published online 9 February 2018
Published in print 8 March 2018
+
Altmetric Logo Icon More Article Metrics


Chemical & Engineering News: Latest News



ACS Axial: Your Bond With Chemistry Research