2017年8月15日火曜日

Sequential Oxidative Conversion of Alchols into Amaides

Ruthenium-Catalyzed Oxidation of Alcohols into Amides

Andrew J. A. Watson^†, Aoife C. Maxwell^‡ and Jonathan M. J. Williams*^†

Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, U.K., and GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

Org. Lett., 2009, 11 (12), pp 2667–2670

DOI: 10.1021/ol900723v

Publication Date (Web): May 15, 2009

Copyright © 2009 American Chemical Society

j.m.j.williams@bath.ac.uk, †

University of Bath.

, ‡

GlaxoSmithKline Research and Development.

Abstract

Abstract Image

The synthesis of secondary amides from primary alcohols and amines has been developed using commercially available [Ru(p-cymene)Cl₂]₂ with bis(diphenylphosphino)butane (dppb) as the catalyst.

Supporting Information

Details of experimental procedures and characterization data are provided. This material is available free of charge via the Internet at http://pubs.acs.org.

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Ruthenium-Catalyzed Oxidation of Alcohols into Amides

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