Aldehyde C-H Arylation 2017

Direct Acylation of Aromatic Compounds

By the Activation of Aldehede with Metal Catalysts;

 

 

http://pubs.acs.org/doi/abs/10.1021/jacs.7b07078?src=recsys

Abstract

 

 

 

A mechanism that enables direct aldehyde C–H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C–H abstraction coupling technology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol.