Reevaluating IDO 2017

Letter to the Editor

Reevaluating the role of IDO1: Examining NAD + metabolism in inflammation

• Peter Kim Moon^a,
• Paras Singh Minhas^{b, ,}

• ^a Department of Biology, Stanford University, Stanford, CA 94305, United States
• ^b Department of Neurology & Neurological Sciences, School of Medicine, Stanford University, Stanford, CA 94305, United States

Received 23 March 2017, Accepted 26 March 2017, Available online 27 March 2017

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https://doi.org/10.1016/j.jneuroim.2017.03.016

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Highlights

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Indoleamine-2,3-dioxygenase (IDO1) upregulation may generate de novo NAD +.

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De novo NAD + provides increased substrate to increase Complex I – IV activities within mitochondria.

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Examining kynurenine pathway and NAD + metabolism within the CNS is necessary to examine the potential impacts of IDO1.

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Corresponding author at: Department of Neurology & Neurological Sciences, 1201 Welch Road, MSLS P250, Stanford, CA 94305, United States.

© 2017 Elsevier B.V. All rights reserved.