ROCK, Rho-kinase

Graphical abstract

Rho-kinase inhibitors developed recently,

classified as isoquinolines, pyridines, indazoles,

pyrazoles or others, are promising candidates

for the treatment of CNS disorders,

cardiovascular diseases, cancer and so on.

 

 

 

Keywords

• RhoA;
• Rho kinase;
• Inhibitors;
• Central nervous system;
• Fasudil

Abbreviations

• ACS, acute coronary syndrome;
• AP-1, activator protein-1;
• AT1, angiotensin II type 1 receptor;
• CNS, central nervous system;
• CPI-17, PKC-potentiated inhibitory protein 17;
• CPK, creatine phosphokinase;
• CRD, C-terminal cysteine-rich domain;
• CRMP-2, collapsin response mediator protein 2;
• DMPK, myotonic dystrophy kinase;
• ERK, extracellular signal-regulated kinase;
• ERM, ezrin/radixin/moesin family;
• ET-1, endothelin-1;
• GAPs, GTPase-activating proteins;
• GDIs, GDP dissociation inhibitors;
• GEFs, guanine nucleotide exchange factors;
• HCC, hepatocellular carcinoma;
• 5-HT, 5-hydroxytryptamine;
• IP3, inositol 1,4,5-trisphosphate;
• LDH, lactate dehydrogenase;
• MCP-1, monocyte chemoattractant protein-1;
• MEK, mitogen-activated protein kinase;
• MES, maximal electroconvulsive shock;
• MLC, myosin light chain;
• MRCK, myotonic dystrophy kinase-related CDC42-binding kinase;
• MYPT-1, myosin phosphatase target subunit 1;
• NLSs, nuclear localization signals;
• OpN, optic nerve;
• PAH, pulmonary arterial hypertension;
• PAI-1, plasminogen activator inhibitor-1;
• PH, pleckstrin homology;
• PTEN, phosphatase and tensin homolog deleted on chromosome 10;
• PTZ, pentylenetetrazole;
• RBD, Rho-binding domain;
• ROCK, Rho-kinase;
• UPS, ubiquitin–proteasome system;
• VA, vasospastic angina;
• VCAM-1, vascular cell adhesion molecule-1;
• VSMC, vascular smooth muscle cell